Manuscripts are still published regularly that are based (and its primary commercial source, turmeric) as an anticancer agent, 10, 11 a therapeutic for Alzheimer’s disease, 12 a treatment for hangovers, 13, 14 erectile dysfunction, 15, 16 baldness, 17, 18 hirsutism, 19 a fertility-boosting, 20 andĬontraceptive 21 extract, collectively establishing Of papers, reviews, patents, and Web sites touting the use of curcumin 5 These cautionary reports appear to have been swept away in the torrent (PK/PD) properties, low efficacy in several disease models, and toxicĮffects under certain testing conditions. The potential “dark side of curcumin”: 5− 9 the drawbacks noted for curcumin include its poor pharmacokinetic/pharmacodynamic 4 Additionally, many researchers have described Of certain ethnic and traditional medicines (TxMs) in medical practiceĪre recent reports labeling curcumin, a constituent of the spice turmericĪnd part of the mixture of compounds referred to as curcuminoids,Īs both a PAINS (pan assay interference compounds) 3 and an IMPS (invalid metabolic panaceas) compound. 1, 2 In marked contradistinction to this claimed vindication of the role Viewed this award as a validation of the general utility of TCMs. Therapy for Plasmodium falciparum malaria. (TCM), Artemisia annua, was developed into an effective Artemisinin, a NP discovered from a traditional Chinese medicine Of artemisinin shared the Nobel Prize in Physiology or Medicine inĢ015 with the discoverers of the anthelmintic avermectin family of This utility was recently recognized on a larger stage, as the discoverer Form the basis for many widely used drugs.
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